Article
Cerebrospinal fluid tau levels increase with age in healthy individuals.
Dementia and geriatric cognitive disorders - 1 Jan 2000
Blomberg M, Jensen M, Basun H, Lannfelt L, Wahlund L O
Abstract excerpt
Cerebrospinal fluid (CSF) tau is a promising biochemical ante-mortem marker for Alzheimer's disease (AD). Levels are increased in AD compared to other dementias, neurological diseases and healthy controls. An age-related decrease in both soluble tau and tau bound to paired helical filaments has been shown in brains from non-demented subjects. To study tau levels in normal ageing, we investigated CSF in 29 healthy...
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