Article
A centuries-long epidemic of scrapie in British sheep?
Trends in microbiology - 1 Feb 2001
Woolhouse M E, Coen P, Matthews L, Foster J D, Elsen J M, Lewis R M, Haydon D T, Hunter N
Abstract excerpt
The apparent persistence of scrapie in British sheep for more than 250 years is difficult to explain. Susceptibility to scrapie is associated with particular alleles at a single locus, the PrP gene. As the only known effect of these alleles is to confer susceptibility to a fatal disease, natural selection is expected to reduce their frequency, as has been observed in practice during scrapie outbreaks in single...
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