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Article

Implications of conflicting associations of the prion protein (PrP) gene with scrapie susceptibility and fitness on the persistence of scrapie.

PloS one - 24 Nov 2009

Doeschl-Wilson Andrea, Sawalha Rami, Gubbins Simon, Villanueva Beatriz

Abstract excerpt

BACKGROUND: Existing mathematical models for scrapie dynamics in sheep populations assume that the PrP gene is only associated with scrapie susceptibility and with no other fitness related traits. This assumption contrasts recent findings of PrP gene associations with post-natal lamb survival in scrapie free Scottish Blackface populations. Lambs with scrapie resistant genotypes were found to have significantly...

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Identifiers

PMID: 19956715
DOI: 10.1371/journal.pone.0007970
PMCID: PMC2776355

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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