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Article

Selection of influenza virus mutants in experimentally infected volunteers treated with oseltamivir.

The Journal of infectious diseases - 15 Feb 2001

Gubareva L V, Kaiser L, Matrosovich M N, Soo-Hoo Y, Hayden F G

Abstract excerpt

Volunteers experimentally infected with influenza A/Texas/36/91 (H1N1) virus and treated with the neuraminidase (NA) inhibitor oseltamivir were monitored for the emergence of drug-resistant variants. Two (4%) of 54 resistant viruses were detected by NA inhibition assay among last-day isolates recovered from 54 drug recipients. They bore a substitution His274Tyr in the NA. Hemagglutinin (HA) variants detected in...

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Identifiers

PMID: 11170976
DOI: 10.1086/318537

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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