Article
Selection and viral load kinetics of an oseltamivir-resistant pandemic influenza A (H1N1) virus in an immunocompromised patient during treatment with neuraminidase inhibitors.
Diagnostic microbiology and infectious disease - 1 Nov 2010
Antón Andrés, López-Iglesias Ana Alicia, Tórtola Teresa, Ruiz-Camps Isabel, Abrisqueta Pau, Llopart Lluís, Marcos María Ángeles, Martínez Miguel Julián, Tudó Griselda, Bosch Francesc, Pahissa Albert, de Anta María Teresa Jiménez, Pumarola Tomàs
Abstract excerpt
Prolonged viral excretion in immunocompromised hosts leads to long oseltamivir treatment and to the subsequent development of oseltamivir-resistant pandemic influenza virus selection. We report the selection and nasopharyngeal shedding kinetics of an oseltamivir-resistant strain in a hospitalized immunocompromised patient with prolonged influenza illness. Viral load quantification and genotyping methods were...
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