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Article

Induction of antigen specific CD4+ T cell responses by invariant chain based DNA vaccines.

Vaccine - 8 Jan 2001

van Tienhoven E A, ten Brink C T, van Bergen J, Koning F, van Eden W, Broeren C P

Abstract excerpt

In this report, the use of DNA vaccination to induce class II restricted antigen specific proliferative responses was studied. To this end, a construct encoding the invariant chain (Ii) was engineered in which the Class II associated invariant chain peptide (CLIP) sequence was replaced by an immunogenic epitope derived form Heat Shock Protein 60, HSP60 178-186. Transfection studies in vitro showed that this...

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Share to Antigens, Differentiation, B-Lymphocyte
Share to CD4-Positive T-Lymphocytes

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chaperonin 60

Share to DNA, Recombinant

Share to Histocompatibility Antigens Class II

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Source

Identifiers

PMID: 11163676
DOI: 10.1016/s0264-410x(00)00330-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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