Article
Endoplasmic reticulum stress-induced formation of transcription factor complex ERSF including NF-Y (CBF) and activating transcription factors 6alpha and 6beta that activates the mammalian unfolded protein response.
Molecular and cellular biology - 1 Feb 2001
Yoshida H, Okada T, Haze K, Yanagi H, Yura T, Negishi M, Mori K
Abstract excerpt
The levels of molecular chaperones and folding enzymes in the endoplasmic reticulum (ER) are controlled by a transcriptional induction process termed the unfolded protein response (UPR). The mammalian UPR is mediated by the cis-acting ER stress response element (ERSE), the consensus sequence of which is CCAAT-N(9)-CCACG. We recently proposed that ER stress response factor (ERSF) binding to ERSE is a heterologous...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.