Article
Rocker is a new variant of the voltage-dependent calcium channel gene Cacna1a.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Feb 2001
Zwingman T A, Neumann P E, Noebels J L, Herrup K
Abstract excerpt
Rocker (gene symbol rkr), a new neurological mutant phenotype, was found in descendents of a chemically mutagenized male mouse. Mutant mice display an ataxic, unstable gait accompanied by an intention tremor, typical of cerebellar dysfunction. These mice are fertile and appear to have a normal life span. Segregation analysis reveals rocker to be an autosomal recessive trait. The overall cytoarchitecture of the...
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