Article
The inhibitory action of sodium arsenite on lipopolysaccharide-induced nitric oxide production in RAW 267.4 macrophage cells: a role of Raf-1 in lipopolysaccharide signaling.
Journal of immunology (Baltimore, Md. : 1950) - 1 Feb 2001
Chakravortty D, Kato Y, Sugiyama T, Koide N, Mu M M, Yoshida T, Yokochi T
Abstract excerpt
The effect of sodium arsenite (SA) on LPS-induced NO production in RAW 267.4 murine macrophage cells was studied. SA pretreatment of LPS-stimulated RAW cells resulted in a striking reduction in NO production. No significant difference in LPS binding was observed between RAW cells pretreated with SA and control untreated RAW cells, suggesting that SA might impair the intracellular signal pathway for NO production....
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