Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Therapeutic Benefit of a Dissociated Glucocorticoid and the Relevance of In Vitro Separation of Transrepression from Transactivation Activity

1 Feb 2001

Abstract excerpt

Glucocorticoids (GCs) are the mainstay of asthma therapy; however, major side effects limit their therapeutic use. GCs influence the expression of genes either by transactivation or transrepression. The antiinflammatory effects of steroids are thought to be due to transrepression and the side effects, transactivation. Recently, a compound, RU 24858, has been identified that demonstrated dissociation between...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adrenal Hormones and Disorders
Share to Asthma and respiratory diseases
Share to Estrogen and related hormone effects

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 11160246
DOI: 10.4049/jimmunol.166.3.1975

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Therapeutic Benefit of a Dissociated Glucocorticoid and the Relevance of In Vitro Separation of Transrepression from Transactivation ActivityPMID 11160246Read ↗

Synthetic Glucocorticoids That Dissociate Transactivation and AP-1 Transrepression Exhibit Antiinflammatory Activity<i>in Vivo</i>Semantic proximity Read ↗

Dissociated non-steroidal glucocorticoid receptor modulators: an update on new compoundsSemantic proximity Read ↗

Discovery of GW 870086: a potent anti‐inflammatory steroid with a unique pharmacological profileSemantic proximity Read ↗

An analysis of glucocorticoid receptor‐mediated gene expression in BEAS‐2B human airway epithelial cells identifies distinct, ligand‐directed, transcription profiles with implications for asthma therapeuticsSemantic proximity Read ↗

Discovery of Compound A - a selective activator of the glucocorticoid receptor with anti-inflammatory and anti-cancer activitySemantic proximity Read ↗

Cross‐talk between pro‐inflammatory transcription factors and glucocorticoidsSemantic proximity Read ↗

Steroid resistance in asthma: mechanisms and treatment options.Semantic proximity Read ↗

Anti-inflammation: Direct Physical Association and Functional Antagonism Between Transcription Factor NF-KB and the Glucocorticoid ReceptorSemantic proximity Read ↗

Anti-inflammatory Actions of Glucocorticoids: Molecular MechanismsSemantic proximity Read ↗

Transcription factor‐mediated molecular mechanisms involved in the functional cross‐talk between cytokines and glucocorticoidsSemantic proximity Read ↗

Glucocorticoid resistance in inflammatory diseases.Semantic proximity Read ↗

New Insights into the Anti-inflammatory Mechanisms of Glucocorticoids: An Emerging Role for Glucocorticoid-Receptor-Mediated TransactivationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.