Synthetic Glucocorticoids That Dissociate Transactivation and AP-1 Transrepression Exhibit Antiinflammatory Activity<i>in Vivo</i>

Abstract excerpt

Some of the most potent antiinflammatory and immunosuppressive agents are synthetic glucocorticoids. However, major side effects severely limit their therapeutic use. The development of improved glucocorticoid-based drugs will require the separation of beneficial from deleterious effects. One possibility toward this goal is to try to dissociate two main activities of glucocorticoids, i.e. transactivation and...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Adrenal Hormones and Disorders
• Share to Cytokine Signaling Pathways and Interactions
• Share to Estrogen and related hormone effects