Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Steroid resistance in asthma: mechanisms and treatment options.

Current allergy and asthma reports - 1 Apr 2008

Adcock Ian M, Ford Paul A, Bhavsar Pank, Ahmad Tehireem, Chung Kian Fan

Abstract excerpt

Glucocorticoid insensitivity presents a profound management problem in patients with asthma because conventional therapies are not effective. Glucocorticoids, acting through the glucocorticoid receptor (GR), are able to selectively repress inflammatory gene expression by utilizing several distinct mechanisms targeting nuclear factor-varphiB and activator protein-1 activation complexes and by effects on...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Asthmatic Agents
Share to Asthma
Share to Drug Resistance

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Glucocorticoids

Share to Receptors, Glucocorticoid

Share to Signal Transduction

Share to Tumor Necrosis Factor-alpha

Source

Identifiers

PMID: 18417060
DOI: 10.1007/s11882-008-0028-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Steroid resistance in asthma: mechanisms and treatment options.PMID 18417060Read ↗

Refractory asthma: mechanisms, targets, and therapySemantic proximity Read ↗

Inflammatory cellular phenotypes and molecular mechanisms of glucocorticoid resistance in patients with bronchial asthma.Semantic proximity Read ↗

Addressing corticosteroid insensitivity in adults with asthma.Semantic proximity Read ↗

Potential Therapeutic Targets for Steroid-Resistant AsthmaSemantic proximity Read ↗

Glucocorticoid resistance in inflammatory diseases.Semantic proximity Read ↗

Genomic and non-genomic actions of glucocorticoids in asthmaSemantic proximity Read ↗

The role of glucocorticoid receptor nuclear trafficking in oxidative stress induced corticosteroid insensitivitySemantic proximity Read ↗

Current concepts in glucocorticoid resistance.Semantic proximity Read ↗

Association of Glucocorticoid Insensitivity with Increased Expression of Glucocorticoid Receptor βSemantic proximity Read ↗

Mechanisms and resistance in glucocorticoid control of inflammationSemantic proximity Read ↗

The Glucocorticoid Receptor: Isoforms, Functions, and Contribution to Glucocorticoid SensitivitySemantic proximity Read ↗

Glucocorticoid receptors: finding the middle groundSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.