Leukemia inhibitory factor inhibits HIV-1 replication and is upregulated in placentae from nontransmitting women

Abstract excerpt

The placenta may play a critical role in inhibiting vertical transmission of HIV-1. Here we demonstrate that leukemia inhibitory factor (LIF) is a potent endogenous HIV-1-suppressive factor produced locally in placentae. In vitro, LIF exerted a potent, gp130-LIFRbeta-dependent, HIV coreceptor-independent inhibition of HIV-1 replication with IC50 values between 0.1 pg/ml and 0.7 pg/ml, depending on the HIV-1...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to HIV/AIDS Research and Interventions
• Share to HIV Research and Treatment
• Share to Reproductive System and Pregnancy