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Article

Vacuolating cytotoxin of Helicobacter pylori plays a role during colonization in a mouse model of infection.

Infection and immunity - 1 Feb 2001

Salama N R, Otto G, Tompkins L, Falkow S

Abstract excerpt

Helicobacter pylori, the causative agent of gastritis and ulcer disease in humans, secretes a toxin called VacA (vacuolating cytotoxin) into culture supernatants. VacA was initially characterized and purified on the basis of its ability to induce the formation of intracellular vacuoles in tissue culture cells. H. pylori strains possessing different alleles of vacA differ in their ability to express active toxin....

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Identifiers

PMID: 11159961
DOI: 10.1128/IAI.69.2.730-736.2001
PMCID: PMC97945

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Vacuolating cytotoxin of Helicobacter pylori plays a role during colonization in a mouse model of infection.PMID 11159961Read ↗

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