Genetic involvement of a cAMP-dependent protein kinase in a G protein signaling pathway regulating morphological and chemical transitions in Aspergillus nidulans.

doi:10.1093/genetics/157.2.591

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Article

Genetic involvement of a cAMP-dependent protein kinase in a G protein signaling pathway regulating morphological and chemical transitions in Aspergillus nidulans.

Genetics - 1 Feb 2001

Shimizu K, Keller N P

Abstract excerpt

In the filamentous fungus Aspergillus nidulans, a heterotrimeric G protein alpha-subunit and an RGS domain protein, encoded by fadA and flbA, respectively, regulate production of the carcinogenic metabolite sterigmatocystin (ST) and asexual spores (i.e., conidia). We investigated the genetic involvement of the cAMP-dependent protein kinase catalytic subunit (PkaA), a potential downstream target of FadA activity,...

Topics

Aspergillus nidulans
Catalytic Domain
Cell Division
Cloning, Molecular
Cosmids
Cyclic AMP
Epistasis, Genetic
Fungal Proteins
GTP-Binding Proteins
Gene Deletion
Gene Expression Regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gene Library

Genetic Linkage

Genotype

Models, Biological

Mutagenesis

Phenotype

Protein Serine-Threonine Kinases

Source

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Identifiers

PMID: 11156981
DOI: 10.1093/genetics/157.2.591
PMCID: PMC1461531

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