Article
Serum endostatin levels are elevated and correlate with serum vascular endothelial growth factor levels in patients with stage IV clear cell renal cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Dec 2000
Feldman A L, Tamarkin L, Paciotti G F, Simpson B W, Linehan W M, Yang J C, Fogler W E, Turner E M, Alexander H R, Libutti S K
Abstract excerpt
Clear cell renal carcinoma (CCRC) is a highly angiogenic tumor known to secrete vascular endothelial cell growth factor (VEGF). Endostatin is an endogenous antiangiogenic agent with antitumor activity in mice. The purpose of this study was to evaluate serum levels of endostatin in normal subjects and in patients with CCRC and to examine the relationship of these levels to circulating VEGF levels. Fifteen patients...
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