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Article

Reversible epithelial to mesenchymal transition and acquired resistance to sunitinib in patients with renal cell carcinoma: evidence from a xenograft study.

Molecular cancer therapeutics - 1 Jun 2010

Hammers Hans J, Verheul Henk M, Salumbides Brenda, Sharma Rajni, Rudek Michelle, Jaspers Janneke, Shah Preeti, Ellis Leigh, Shen Li, Paesante Silvia, Dykema Karl, Furge Kyle, Teh Bin T, Netto George, Pili Roberto

Abstract excerpt

Tyrosine kinase inhibitors (TKI) targeting angiogenesis via inhibition of the vascular endothelial growth factor pathway have changed the medical management of metastatic renal cell carcinoma. Although treatment with TKIs has shown clinical benefit, these drugs will eventually fail patients. The...

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Identifiers

PMID: 20501804
DOI: 10.1158/1535-7163.MCT-09-1106
PMCID: PMC3049816

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20501804-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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