Article
Exploring steric constraints on protein mutations using MAGE/PROBE.
Protein science : a publication of the Protein Society - 1 Nov 2000
Word J M, Bateman R C, Presley B K, Lovell S C, Richardson D C
Abstract excerpt
When planning a mutation to test some hypothesis, one crucial question is whether the new side chain is compatible with the existing structure; only if it is compatible can the interpretation of mutational results be straightforward. This paper presents a simple way of using the sensitive geometry of all-atom contacts (including hydrogens) to answer that question. The interactive MAGE/PROBE system lets the...
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