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Article

Metformin decreases IGF1-induced cell proliferation and protein synthesis through AMP-activated protein kinase in cultured bovine granulosa cells.

Reproduction (Cambridge, England) - 1 Feb 2010

Tosca Lucie, Ramé Christelle, Chabrolle Christine, Tesseraud Sophie, Dupont Joëlle

Abstract excerpt

Although its mechanism of action is still unclear, metformin is an anti-diabetic drug effective to restore cyclicity and spontaneous ovulation in women with polycystic ovary syndrome. It may also reduce the risk of cancer. We have recently shown that metformin treatment decreases steroidogenesis...

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Source

Identifiers

PMID: 19906888
DOI: 10.1530/REP-09-0351

Genes

IGF1
MAPK3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19906888-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Metformin decreases IGF1-induced cell proliferation and protein synthesis through AMP-activated protein kinase in cultured bovine granulosa cells.PMID 19906888Read ↗

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