Extreme discordant phenotype methodology: an intuitive approach to clinical pharmacogenetics.

Abstract excerpt

Pharmacogenetics represents "the study of variability in drug response due to heredity". Of the more than six dozen pharmacogenetic differences described in the medical literature, the majority of these variations occurs in drug-metabolizing enzyme genes and others in drug receptor and drug transporter genes, whereas many others have not yet been explained on a molecular basis. It is clear that "drug efficacy" or...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Drug Transport and Resistance Mechanisms
• Share to Genomics and Rare Diseases