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Article

Copper-modulated gene expression and senescence in the filamentous fungus Podospora anserina.

Molecular and cellular biology - 1 Jan 2001

Borghouts C, Werner A, Elthon T, Osiewacz H D

Abstract excerpt

We have previously shown that the control of cellular copper homeostasis by the copper-modulated transcription factor GRISEA has an important impact on the phenotype and lifespan of Podospora anserina. Here we demonstrate that copper depletion leads to the induction of an alternative respiratory pathway and to an increase in lifespan. This response compensates mitochondrial dysfunctions via the expression of...

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Identifiers

PMID: 11134328
DOI: 10.1128/MCB.21.2.390-399.2001
PMCID: PMC86578

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Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Copper-modulated gene expression and senescence in the filamentous fungus Podospora anserina.PMID 11134328Read ↗

Copper homeostasis and aging in the fungal model system Podospora anserina: differential expression of PaCtr3 encoding a copper transporter.Semantic proximity Read ↗

GRISEA, a putative copper-activated transcription factor from Podospora anserina involved in differentiation and senescence.Semantic proximity Read ↗

A Genome-Wide Longitudinal Transcriptome Analysis of the Aging Model Podospora anserineSemantic proximity Read ↗

GRISEA, a copper-modulated transcription factor from Podospora anserina involved in senescence and morphogenesis, is an ortholog of MAC1 in Saccharomyces cerevisiae.Semantic proximity Read ↗

Mitochondrial DNA rearrangements of Podospora anserina are under the control of the nuclear gene grisea.Semantic proximity Read ↗

Molecular control of copper homeostasis in filamentous fungi: increased expression of a metallothionein gene during aging of Podospora anserina.Semantic proximity Read ↗

Age-Related Cellular Copper Dynamics in the Fungal Ageing Model Podospora anserina and in Ageing Human FibroblastsSemantic proximity Read ↗

Mutations in two zinc-cluster proteins activate alternative respiratory and gluconeogenic pathways and restore senescence in long-lived respiratory mutants of Podospora anserina.Semantic proximity Read ↗

Impact of a disruption of a pathway delivering copper to mitochondria on Podospora anserina metabolism and life span.Semantic proximity Read ↗

Deletion of PaAif2 and PaAmid2, two genes encoding mitochondrial AIF-like oxidoreductases of Podospora anserina, leads to increased stress tolerance and lifespan extensionSemantic proximity Read ↗

Increasing mitochondrial superoxide dismutase abundance leads to impairments in protein quality control and ROS scavenging systems and to lifespan shortening.Semantic proximity Read ↗

PaGrg1, a glucose-repressible gene of Podospora anserina that is differentially expressed during lifespan.Semantic proximity Read ↗

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