Article
PaGrg1, a glucose-repressible gene of Podospora anserina that is differentially expressed during lifespan.
Current genetics - 1 Jun 1999
Kimpel E, Osiewacz H D
Abstract excerpt
A loss-of-function mutation in Grisea, a gene of Podospora anserina that was previously shown to code for a copper-modulated transcription factor, leads to a significant increase in lifespan. In an attempt to identify and to isolate potential target genes controlled by GRISEA, a RT-differential-display screen was performed. This approach resulted in the identification of a gene, PaGrg1, that is differentially...
Topics
- Amino Acid Sequence
- Ascomycota
- Base Sequence
- Cellular Senescence
- Cloning, Molecular
- Fungal Proteins
- Gene Expression Regulation, Fungal
- Glucose
- Heat-Shock Proteins
- Molecular Sequence Data
- Mutation
- Transcription Factors
- Transcription, Genetic