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Article

Herpes Simplex Virus Triggers and Then Disarms a Host Antiviral Response

15 Jan 2001

Abstract excerpt

Virus infection induces an antiviral response that is predominantly associated with the synthesis and secretion of soluble interferon. Here, we report that herpes simplex virus type 1 virions induce an interferon-independent antiviral state in human embryonic lung cells that prevents plaquing of a variety of viruses. Microarray analysis of 19,000 human expressed sequence tags revealed induction of a limited set...

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PMID: 11134288
DOI: 10.1128/jvi.75.2.750-758.2001

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