Article
Allelic variants of the follistatin gene in polycystic ovary syndrome.
The Journal of clinical endocrinology and metabolism - 1 Dec 2000
Urbanek M, Wu X, Vickery K R, Kao L C, Christenson L K, Schneyer A, Legro R S, Driscoll D A, Strauss J F, Dunaif A, Spielman R S
Abstract excerpt
In an earlier study of 37 candidate genes for polycystic ovary syndrome (PCOS), the strongest evidence for genetic linkage was found with the region of the follistatin gene. We have now carried out studies to detect variation in the follistatin gene and assess its relevance to PCOS. By sequencing the gene in 85 members of 19 families of PCOS patients, we found sequence variants at 17 sites. Of these, 16 sites...
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