Article
The role of genes and environment in the etiology of PCOS.
Endocrine - 1 Aug 2006
Diamanti-Kandarakis Evanthia, Kandarakis Helen, Legro Richard S
Abstract excerpt
Both genes and the environment contribute to PCOS. Obesity, exacerbated by poor dietary choices and physical inactivity, worsens PCOS in susceptible individuals. The role of other environmental modifiers such as infectious agents or toxins are speculative. Phenotype confusion has characterized genetic studies of PCOS. Although several loci have been proposed as PCOS genes including CYP11A, the insulin gene, the...
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