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Genetic analysis of growth inhibition of yeast cells caused by expression of Aspergillus oryzae RNase T1.

Bioscience, biotechnology, and biochemistry - 1 Oct 2000

Nonaka G, Ishikawa T, Liu T T, Nakajima H, Kitamoto K

Abstract excerpt

Even though most fungal hydrolytic enzymes have been successfully secreted in S. cerevisiae cells by expression of corresponding cDNA, overexpression of A. oryzae RNase T1 causes severe growth inhibition in yeast. We observed that yeast strains carrying RNase T1 cDNA under control of the GAL1 promoter with a single-copy vector were able to grow on galactose medium while those with a multi-copy vector were not. It...

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PMID: 11129588
DOI: 10.1271/bbb.64.2152

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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