Article
Cellular responses to the expression of unstable secretory proteins in the filamentous fungus Aspergillus oryzae.
Applied microbiology and biotechnology - 1 Mar 2017
Yokota Jun-Ichi, Shiro Daisuke, Tanaka Mizuki, Onozaki Yasumichi, Mizutani Osamu, Kakizono Dararat, Ichinose Sakurako, Shintani Tomoko, Gomi Katsuya, Shintani Takahiro
Abstract excerpt
Filamentous fungi are often used as cell factories for recombinant protein production because of their ability to secrete large quantities of hydrolytic enzymes. However, even using strong transcriptional promoters, yields of nonfungal proteins are generally much lower than those of fungal proteins. Recent analyses revealed that expression of certain nonfungal secretory proteins induced the unfolded protein...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
