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Article

The protective effect of hormone-replacement therapy on fracture risk is modulated by estrogen receptor alpha genotype in early postmenopausal women.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Dec 2000

Salmén T, Heikkinen A M, Mahonen A, Kröger H, Komulainen M, Saarikoski S, Honkanen R, Mäenpää P H

Abstract excerpt

Genetic factors regulate bone mineral density (BMD) and possibly development of osteoporosis. It has been suggested that estrogen receptor alpha (ERalpha) genotype is associated with BMD, but the association between ERalpha genotype, fracture risk, and postmenopausal hormone replacement therapy (HRT) has not been studied. Therefore, we evaluated whether ERalpha polymorphism is associated with fracture risk in a...

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Identifiers

PMID: 11127213
DOI: 10.1359/jbmr.2000.15.12.2479

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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