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Article

Expansion of CUG RNA repeats causes stress and inhibition of translation in myotonic dystrophy 1 (DM1) cells

17 May 2010

Abstract excerpt

ABSTRACT The purpose of this study was to investigate the role of the mutant CUGn RNA in the induction of stress in type 1 myotonic dystrophy (DM1) cells and in the stressmediated inhibition of protein translation in DM1. To achieve our goals, we performed HPLC‐based purification of stress granules (SGs), immunoanalysis of SGs with stress markers TIA‐1, CUGBP1, and ph‐eIF2, site‐specific mutagenesis, and...

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PMID: 20479119
DOI: 10.1096/fj.09-151159

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