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Article

Leptin receptor Gln223Arg variant is associated with a cluster of metabolic abnormalities in response to long-term overfeeding.

Journal of internal medicine - 1 Nov 2000

Ukkola O, Tremblay A, Després J P, Chagnon Y C, Campfield L A, Bouchard C

Abstract excerpt

OBJECTIVES: The role of the leptin receptor (LEPR) gene Gln223Arg polymorphism on the metabolic and body composition changes in response to overfeeding was studied. SUBJECTS: Twelve pairs of male monozygotic twins ate a 4.2 MJ day-1 energy surplus, 6 days week-1, during a period of 100 days. RESULTS: Overfeeding induced a significantly greater increase in glucose (P = 0.001 for percentage change) and insulin (P =...

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Source

Identifiers

PMID: 11123508
DOI: 10.1046/j.1365-2796.2000.00751.x

Genes

LEPR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Leptin receptor Gln223Arg variant is associated with a cluster of metabolic abnormalities in response to long-term overfeeding.PMID 11123508Read ↗

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