Article
Atypical osteosarcomas in Werner Syndrome (adult progeria).
Japanese journal of cancer research : Gann - 1 Dec 2000
Ishikawa Y, Miller R W, Machinami R, Sugano H, Goto M
Abstract excerpt
Werner syndrome (WS), adult progeria, is more common in Japan than elsewhere. It predisposes to osteosarcoma (OS) and five other rare tumors. To determine if and how OS is atypical in this genetic disorder, we studied the characteristics of ten Japanese cases with respect to clinical features, pathology, and radiographs, and compared them with a hospital series of 36 skeletal OS with the same atypical age-range,...
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