Article
Diagnostic criteria for Werner syndrome based on Japanese nationwide epidemiological survey.
Geriatrics & gerontology international - 1 Apr 2013
Takemoto Minoru, Mori Seijiro, Kuzuya Masafumi, Yoshimoto Shinya, Shimamoto Akira, Igarashi Masahiko, Tanaka Yasuhito, Miki Tetsuro, Yokote Koutaro
Abstract excerpt
AIM: Werner syndrome (WS) is an autosomal recessive disorder of progeroid symptoms and signs. It is caused by mutations in the WRN gene, which encodes a RecQ DNA helicase. The aim of this study was to revise the diagnostic criteria for Japanese Werner syndrome. METHODS: A nationwide epidemiological study was carried out from 2009 to 2011, involving 6921 surveys sent to hospitals with more than 200 beds to assess...
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