Article
Fibroblasts from different body parts exhibit distinct phenotypes in adult progeria Werner syndrome.
Aging - 24 Feb 2021
Kato Hisaya, Maezawa Yoshiro, Takayama Naoya, Ouchi Yasuo, Kaneko Hiyori, Kinoshita Daisuke, Takada-Watanabe Aki, Oshima Motohiko, Koshizaka Masaya, Ogata Hideyuki, Kubota Yoshitaka, Mitsukawa Nobuyuki, Eto Koji, Iwama Atsushi, Yokote Koutaro
Abstract excerpt
Werner syndrome (WS), also known as adult progeria, is characterized by accelerated aging symptoms from a young age. Patients with WS experience painful intractable skin ulcers with calcifications in their extremities, subcutaneous lipoatrophy, and sarcopenia. However, there is no significant abnormality in the trunk skin, where the subcutaneous fat relatively accumulates. The cause of such differences between...
Topics
- Abdomen
- Aging
- Cellular Senescence
- Fibroblasts
- Foot
- Gene Expression Profiling
- Human Body
- Humans
- Osteogenesis
- Phenotype