Article
Conceptual models for the initiation of hepatitis B virus-associated hepatocellular carcinoma.
Liver international : official journal of the International Association for the Study of the Liver - 1 Jul 2015
Tu Thomas, Budzinska Magdalena A, Shackel Nicholas A, Jilbert Allison R
Abstract excerpt
Although chronic hepatitis B virus (HBV) infection is a known risk factor for the development of hepatocellular carcinoma (HCC), the steps involved in the progression from normal liver to HCC are poorly understood. In this review, we apply five conceptual models, previously proposed by Vineis et al. to explain carcinogenesis in general, to explore the possible steps involved in the initiation and evolution of...
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