Article
No association of an insertion/deletion polymorphism in the angiotensin I converting enzyme gene with bipolar or unipolar affective disorders.
American journal of medical genetics - 4 Dec 2000
Furlong R A, Keramatipour M, Ho L W, Rubinsztein J S, Michael A, Walsh C, Paykel E S, Rubinsztein D C
Abstract excerpt
A recent Japanese study on the angiotensin I converting enzyme gene (ACE) insertion/deletion polymorphism reported that both the D allele (P < 0.02) and the DD genotype (P < 0.002) were significantly more frequent in affective disorder cases than in controls [Arinami et al., 1996: Biol Psychiatry 40:1122-1127]. A replication study was performed by using 157 bipolar I affective disorder cases, 169 major depressive...
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