Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Disruption of the protein C inhibitor gene results in impaired spermatogenesis and male infertility

15 Dec 2000

Abstract excerpt

Protein C inhibitor (PCI) is a nonspecific, heparin-binding serpin (serine protease inhibitor) that inactivates many plasmatic and extravascular serine proteases by forming stable 1:1 complexes. Proteases inhibited by PCI include the anticoagulant activated protein C, the plasminogen activator urokinase, and the sperm protease acrosin. In humans PCI circulates as a plasma protein but is also present at high...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood Coagulation and Thrombosis Mechanisms
Share to Coagulation, Bradykinin, Polyphosphates, and Angioedema
Share to Protease and Inhibitor Mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 11120760
DOI: 10.1172/jci10768

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Disruption of the protein C inhibitor gene results in impaired spermatogenesis and male infertilityPMID 11120760Read ↗

Absence of mutations in the PCI gene in subfertile men.Semantic proximity Read ↗

Impaired fertility in mice deficient for the testicular germ-cell protease PC4Semantic proximity Read ↗

Evidence for similar expression of protein C inhibitor and the urokinase-type plasminogen activator system during mouse testis development.Semantic proximity Read ↗

The testis-specific serine proteases PRSS44, PRSS46, and PRSS54 are dispensable for male mouse fertility†Semantic proximity Read ↗

Epididymal C4b-binding protein is processed and degraded during transit through the duct and is not essential for fertility.Semantic proximity Read ↗

Male fertility defects in mice lacking the serine protease inhibitor protease nexin-1.Semantic proximity Read ↗

Disruption of the murine PIASx gene results in reduced testis weightSemantic proximity Read ↗

Mice with a severe deficiency in protein C display prothrombotic and proinflammatory phenotypes and compromised maternal reproductive capabilities.Semantic proximity Read ↗

Complexin-I-deficient sperm are subfertile due to a defect in zona pellucida penetration.Semantic proximity Read ↗

SERPINE2, a Serine Protease Inhibitor Extensively Expressed in Adult Male Mouse Reproductive Tissues, May Serve as a Murine Sperm Decapacitation Factor1Semantic proximity Read ↗

Sperm from Mice Genetically Deficient for the PCSK4 Proteinase Exhibit Accelerated Capacitation, Precocious Acrosome Reaction, Reduced Binding to Egg Zona Pellucida, and Impaired Fertilizing Ability1Semantic proximity Read ↗

Spermatogenic cells distal to the blood-testis barrier in rats lack C3 convertase regulators and may be at risk of complement-mediated injury.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.