Article
Epididymal C4b-binding protein is processed and degraded during transit through the duct and is not essential for fertility.
Immunobiology - 1 Apr 2015
Nonaka Mayumi I, Zsigmond Eva, Kudo Akihiko, Kawakami Hayato, Yoshida Kaoru, Yoshida Manabu, Kawano Natsuko, Miyado Kenji, Nonaka Masaru, Wetsel Rick A
Abstract excerpt
C4b-binding protein (C4BP) is known as one of the circulating complement regulators that prevents excessive activation of the host-defense complement system. We have reported previously that C4BP is expressed abundantly in the rodent epididymis, one of the male reproductive organs connecting the testis and vas deferens, where immature spermatozoa acquire their motility and fertilizing ability during their transit...
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