Article
Male fertility defects in mice lacking the serine protease inhibitor protease nexin-1.
Proceedings of the National Academy of Sciences of the United States of America - 13 Mar 2001
Murer V, Spetz J F, Hengst U, Altrogge L M, de Agostini A, Monard D
Abstract excerpt
Understanding infertility and sterility requires knowledge of the molecular mechanisms underlying sexual reproduction. We have found that male mice deficient for the gene encoding the protease inhibitor protease nexin-1 (PN-1) show a marked impairment in fertility from the onset of sexual maturity. Absence of PN-1 results in altered semen protein composition, which leads to inadequate semen coagulation and...
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