Isolation and characterization of Saccharomyces cerevisiae mutants with derepressed thiamine gene expression.

Abstract excerpt

Using a THI4-lacZ reporter gene, mutant strains have been isolated that display constitutive expression of thiamine genes in the presence of normally repressing levels of exogenous thiamine. In total, eight strains were isolated in which this derepressed expression on thiamine (Det(-)) phenotype was the result of single gene mutations. The Det(-) mutations of three of these strains were partially dominant in a...

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