Article
Mutational definition of RNA-binding and protein-protein interaction domains of heterogeneous nuclear RNP C1.
The Journal of biological chemistry - 9 Mar 2001
Wan L, Kim J K, Pollard V W, Dreyfuss G
Abstract excerpt
The heterogeneous nuclear ribonucleoprotein (hn- RNP) C proteins, among the most abundant pre-mRNA-binding proteins in the eukaryotic nucleus, have a single RNP motif RNA-binding domain. The RNA-binding domain (RBD) is comprised of approximately 80-100 amino acids, and its structure has been determined. However, relatively little is known about the role of specific amino acids of the RBD in the binding to RNA. We...
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