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Article

Population structure in admixed populations: effect of admixture dynamics on the pattern of linkage disequilibrium.

American journal of human genetics - 1 Jan 2001

Pfaff C L, Parra E J, Bonilla C, Hiester K, McKeigue P M, Kamboh M I, Hutchinson R G, Ferrell R E, Boerwinkle E, Shriver M D

Abstract excerpt

Gene flow between genetically distinct populations creates linkage disequilibrium (admixture linkage disequilibrium [ALD]) among all loci (linked and unlinked) that have different allele frequencies in the founding populations. We have explored the distribution of ALD by using computer simulation of two extreme models of admixture: the hybrid-isolation (HI) model, in which admixture occurs in a single generation,...

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PMID: 11112661
DOI: 10.1086/316935
PMCID: PMC1234913

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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