Article
Phenotype determination of a common Pro-Leu polymorphism in human glutathione peroxidase 1.
Blood cells, molecules & diseases - 1 Oct 2000
Forsberg L, de Faire U, Marklund S L, Andersson P M, Stegmayr B, Morgenstern R
Abstract excerpt
Oxidative stress has been implicated in human illness such as cardiovascular and neurodegenerative disease. The genetic mechanisms involved are only poorly understood. Here we describe the determination of the allelic frequency and phenotype of a common polymorphism in Se-dependent glutathione peroxidase 1 (GPX1) in Finnish/Swedish populations. A proline/leucine variant occurs at position 197 close to the...
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