Article
Novel Intracellular SbV reducing activity correlates with antimony susceptibility in Leishmania donovani.
The Journal of biological chemistry - 9 Feb 2001
Shaked-Mishan P, Ulrich N, Ephros M, Zilberstein D
Abstract excerpt
The standard treatment of human visceral leishmaniasis involves the use of pentavalent antimony (Sb(V)). Its mechanism of action is unknown because of the limited information available about intracellular antimony metabolism and about the genes that regulate these processes. Herein, flow injection-inductively coupled plasma mass spectrometry (ICP-MS), flow injection hydride generation ICP-MS, and ion...
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