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Article

Fibrillin-1, a calcium binding protein of extracellular matrix.

Biochimica et biophysica acta - 20 Dec 2000

Handford P A

Abstract excerpt

Fibrillin-1 is a large extracellular matrix glycoprotein which assembles to form 10-12 nm microfibrils in extracellular matrix. Mutations in the human fibrillin-1 gene (FBN-1) cause the connective tissue disease Marfan syndrome and related disorders, which are characterised by defects in the skeletal, cardiovascular and ocular systems of the body. Fibrillin-1 has a striking modular organisation which is dominated...

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Identifiers

PMID: 11108952
DOI: 10.1016/s0167-4889(00)00085-9

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