Article
The common C-terminal sequences of substance P and neurokinin A contact the same region of the NK-1 receptor.
FEBS letters - 1 Dec 2000
Bremer A A, Leeman S E, Boyd N D
Abstract excerpt
Although neurokinin A (NKA), a tachykinin peptide with sequence homology to substance P (SP), is a weak competitor of radiolabeled SP binding to the NK-1 receptor (NK-1R), more recent direct binding studies using radiolabeled NKA have demonstrated an unexpected high-affinity interaction with this receptor. To document the site of interaction between NKA and the NK-1R, we have used a photoreactive analogue of NKA...
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