Article
Interplay between estrogen receptor and AKT in estradiol-induced alternative splicing.
BMC medical genomics - 11 Jun 2013
Bhat-Nakshatri Poornima, Song Eun-Kyung, Collins Nikail R, Uversky Vladimir N, Dunker A Keith, O'Malley Bert W, Geistlinger Tim R, Carroll Jason S, Brown Myles, Nakshatri Harikrishna
Abstract excerpt
BACKGROUND: Alternative splicing is critical for generating complex proteomes in response to extracellular signals. Nuclear receptors including estrogen receptor alpha (ERα) and their ligands promote alternative splicing. The endogenous targets of ERα:estradiol (E2)-mediated alternative splicing and the influence of extracellular kinases that phosphorylate ERα on E2-induced splicing are unknown. METHODS: MCF-7...
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