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Article

Most microsatellite unstable sporadic colorectal carcinomas carry MBD4 mutations.

British journal of cancer - 1 Dec 2000

Bader S, Walker M, Harrison D

Abstract excerpt

The MBD4 gene is involved in the repair of mutation at methyl-CpG dinucleotides. In microsatellite unstable tumours MBD4 can itself be mutated at an exonic polynucleotide tract. By analysing DNA from microdissected tumour samples we have found that both frequency and pattern of mutation are more significant than originally reported.

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 11104560
DOI: 10.1054/bjoc.2000.1482
PMCID: PMC2363466

Genes

MBD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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