Article
Use of closely related affected individuals for the genetic study of complex diseases in founder populations.
American journal of human genetics - 1 Jan 2001
Bourgain C, Génin E, Holopainen P, Mustalahti K, Mäki M, Partanen J, Clerget-Darpoux F
Abstract excerpt
We propose a method, the maximum identity length contrast (MILC) statistic, to locate genetic risk factors for complex diseases in founder populations. The MILC approach compares the identity length of parental haplotypes that are transmitted to affected offspring with the identity length of those that are not transmitted to affected offspring. Initially, the statistical properties of the method were assessed...
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