Use of closely related affected individuals for the genetic study of complex diseases in founder populations.

doi:10.1086/316933

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Article

Use of closely related affected individuals for the genetic study of complex diseases in founder populations.

American journal of human genetics - 1 Jan 2001

Bourgain C, Génin E, Holopainen P, Mustalahti K, Mäki M, Partanen J, Clerget-Darpoux F

Abstract excerpt

We propose a method, the maximum identity length contrast (MILC) statistic, to locate genetic risk factors for complex diseases in founder populations. The MILC approach compares the identity length of parental haplotypes that are transmitted to affected offspring with the identity length of those that are not transmitted to affected offspring. Initially, the statistical properties of the method were assessed...

Topics

Celiac Disease
Chromosome Mapping
Computer Simulation
Female
Finland
Founder Effect
Gene Frequency
Genetic Predisposition to Disease
HLA Antigens
Haplotypes
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Matched-Pair Analysis

Microsatellite Repeats

Nuclear Family

Pedigree

Research Design

Sample Size

Source

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Identifiers

PMID: 11102286
DOI: 10.1086/316933
PMCID: PMC1234909

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-11102286-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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