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Article

Walker A lysine mutations of TAP1 and TAP2 interfere with peptide translocation but not peptide binding.

The Journal of biological chemistry - 9 Mar 2001

Lapinski P E, Neubig R R, Raghavan M

Abstract excerpt

We generated mutants of the transporter associated with antigen-processing subunits TAP1 and TAP2 that were altered at the conserved lysine residue in the Walker A motifs of the nucleotide binding domains (NBD). In other ATP binding cassette transporters, mutations of the lysine have been shown to reduce or abrogate the ATP hydrolysis activity and in some cases impair nucleotide binding. Mutants TAP1(K544M) and...

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Source

Identifiers

PMID: 11099504
DOI: 10.1074/jbc.M009448200

Genes

TAP1
TAP2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Walker A lysine mutations of TAP1 and TAP2 interfere with peptide translocation but not peptide binding.PMID 11099504Read ↗

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