Article
CF gene and cystic fibrosis transmembrane conductance regulator expression in autosomal dominant polycystic kidney disease.
Journal of the American Society of Nephrology : JASN - 1 Dec 2000
Persu Alexandre, Devuyst Olivier, Lannoy Nathalie, Materne Roland, Brosnahan Godela, Gabow Patricia A, Pirson Yves, Verellen-Dumoulin Christine
Abstract excerpt
Disease-modifying genes might participate in the significant intrafamilial variability of the renal phenotype in autosomal dominant polycystic kidney disease (ADPKD). Cystic fibrosis (CF) transmembrane conductance regulator (CFTR) is a chloride channel that promotes intracystic fluid secretion, and thus cyst progression, in ADPKD. The hypothesis that mutations of the CF gene, which encodes CFTR, might be...
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